Disruptions in epidermal differentiation underlie more than 100 genetic skin conditions with varied clinical and histopathological features. Our group is interested in discovering new protein-coding and noncoding regulators of skin homeostasis and establishing their epistatic relationships within key signaling networks.

We helped identify the first lncRNAs involved in somatic stem cell differentiation, including the ANCR stem cell lncRNA [Genes & Development (2012)] and the terminal differentiation lncRNA, TINCR [Nature (2013)]. Given the reciprocal relationship between homeostasis and tumorigenesis, discovery of previously unappreciated mechanisms of cancer progression through a deeper understanding of essential homeostatic regulators is another major focus of our lab.